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. 2019 Nov 19;17:149. doi: 10.1186/s12964-019-0468-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CTB destroyed mitochondrial structure and function of hepatoma cells. SMMC-7721 cells were treated with different CTB concentrations (0, 1, 2, 4 μM) for 24 h. a Janus green staining for detecting mitochondrial activity. Representative photographs were shown. Scale bar: 50 μm b Observation of mitochondrial morphology by Transmission Electron Microscope (TEM). Scale bar: 0.2 μm. c Effect of CTB on MMP (ΔΨm) was determined in SMMC-7721 cells by JC-1 staining. Scale bar: 50 μm. d The opening of mPTP was detected by Rhodamine123 staining. Scale bar: 50 μm. e ATP generation was detected by ATP Detection Kit. Scale bar: 50 μm. Scale bar: 50 μm. Data are represented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001 vs Control