Table 1.
Parameters of biochemistry, transthoracic echocardiography, blood gas analysis, and right heart catheterization in the two patients with multiple sclerosis.
| Parameters | Patient 1 at diagnosis | Patient 1 after 7 years of PAH treatment | Patient 2 at diagnosis | Patient 2 after 6 month of PAH treatment |
|---|---|---|---|---|
| NT-proBNP (pmol/l) | 207 | 10 | 333 | 76 |
| LVEF (%) | 65 | 70 | 74 | 87 |
| 6 MWD (m) | 100 | 412 | 400 | 510 |
| pO2 at rest (mmHg) | 85 | 76 | 87 | 92 |
| pO2 after 6MWT (mmHg) | n.d. | n.d. | 83 | 72 |
| pCO2 at rest (mmHg) | 29 | 38 | 31 | 30 |
| pCO2 after 6MWT (mmHg) | n.d. | n.d. | 23 | 32 |
| DLCO (%) | 49 | 53 | 53 | 57 |
| DLCO/VA (%) | 55 | 60 | 92 | 66 |
| FVC (%) | 81 | 81 | 43 | 84 |
| FEV1 (l/min) | 2.82 | 2.66 | 1.72 | 1.99 |
| PAP mean (sys/dia) (mmHg) | 66 (101/51) | 29 (48/19) | 52 (84/ 36) | 38 (65/ 24) |
| CI (l/min/m2) | 1.5 | 2.7 | 1.56 | 2.71 |
| CO (l/min) | 2.90 | 5.2 | 2.57 | 4.78 |
| PAWP (mmHg) | 12 | 9 | 6 | 7 |
| CVP (mmHg) | 14 | 8 | 9 | 6 |
| PVR (WU) | 18.6 | 3.8 | 18 | 6.4 |
PAH: pulmonary arterial hypertension; NT-proBNP: N-terminal pro brain natriuretic peptide; LVEF: left ventricular ejection fraction; 6 MWD: 6 minute walking distance; pO2: oxygen partial pressure; pCO2: carbon dioxide partial pressure; DLCO: transfer factor of the lung for carbon monoxide; DLCO/VA: Krogh factor; FVC: functional vital capacity; FEV1: forced expiratory volume in 1 s; PAP: mean (sys/dia) pulmonary arterial pressure mean (systolic/diastolic); CI: cardiac index; CO: cardiac output; PAWP: pulmonary arterial wedge pressure; CVP: central venous pressure; PVR: pulmonary vascular resistance; n.d.: not determined.