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. 2019 Nov 19;19:317. doi: 10.1186/s12906-019-2686-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of SMI on heart functional parameters after administration of DOX-inducedfrom control group (a), DOX group (b), SM injection group (c), co-treatment with DOX and SMI (0.5 g/kg) group (d), co-treatment with DOX and SMI (1.5 g/kg) group (e), co-treatment with DOX and SMI (5 g/kg) group (f) and the co-treatment with DOX and SMI (5 g/kg)) after treating (g). Representative M-mode echocardiograms of ICR mice. (h) Heart rate. (i) Cardiac output. (j) Ejection fraction. (k) Shortening index. The data are expressed as the mean ± S.D.; n = 10 in each group; *, significantly different (P < 0.05) from respective values in the control group; #, significantly different (P < 0.05) from respective values in the DOX group