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. 2019 Nov 19;20:243. doi: 10.1186/s13059-019-1859-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Association between DMRs and metabolic traits. a The distribution of the number of significant DMRs per trait. b The distribution of the number of associated metabolic traits per DMR. c The proportion of DMRs that are associated with metabolic traits but not with SNPs. d A simplified pathway for chrysoeriol di-C-hexoside (chr di-C) synthesis. The solid line represents a one-step reaction, and the dashed line represents a multi-step reaction. e GWAS result of chr di-C using either SNPs (light color) or DMRs (dark color). The horizontal dashed lines are the cutoff for SNPs (thinner) and DMRs (thicker)