Table 3.
Acute toxicities in the 730 NPC patients
| Acute Toxicity | Nimotuzumab Arm N = 184(%) |
No Nimotuzumab Arm N = 546 |
P value |
|---|---|---|---|
| Anemia | 0.920 | ||
| G0-G1 | 137(74.5) | 416(76.2) | |
| G2 | 36(19.6) | 98(17.9) | |
| G3 | 9(4.0) | 27(4.9) | |
| G4 | 2(1.1) | 5(0.9) | |
| Thrombocytopenia | 0.541 | ||
| G0-G1 | 164(89.1) | 464(85.0) | |
| G2 | 16(8.7) | 58(10.6) | |
| G3 | 4(2.2) | 21(3.8) | |
| G4 | 0(0.0) | 3(0.5) | |
| Leukopenia | 0.845 | ||
| G0-G1 | 122(66.3) | 370(67.8) | |
| G2 | 33(17.9) | 101(18.5) | |
| G3 | 27(14.7) | 7113.0() | |
| G4 | 2(1.1) | 4(0.7) | |
| Neutropenia | 0.154 | ||
| G0-G1 | 139(75.5) | 386(70.7) | |
| G2 | 39(21.2) | 118(21.6) | |
| G3 | 5(2.7) | 38(7.0) | |
| G4 | 1(0.5) | 4(0.7) | |
| Skin reaction | 0.434 | ||
| G0-G1 | 126(68.5) | 381(69.8) | |
| G2 | 46(25.0) | 117(21.4) | |
| G3 | 12(6.5) | 48(8.8) | |
| Mucositis | 0.728 | ||
| G0-G1 | 67(36.4) | 189(34.6) | |
| G2 | 73(39.7) | 228(41.8) | |
| G3 | 38(20.7) | 102(18.7) | |
| G4 | 6(3.3) | 27(4.9) | |
| Nausea | 0.394 | ||
| G0-G1 | 62(37.8) | 193(35.3) | |
| G2 | 71(43.3) | 214(39.2) | |
| G3 | 28(17.1) | 126(23.1) | |
| G4 | 3(1.8) | 13(2.4) | |
| Vomiting | 0.990 | ||
| G0-G1 | 138(75.0) | 412(75.5) | |
| G2 | 24(13.0) | 68(12.5) | |
| G3 | 20(10.9) | 61(11.2) | |
| G4 | 2(1.1) | 5(0.9) | |
| Diarrhea | 0.495 | ||
| G0-G1 | 146(79.3) | 437(80.0) | |
| G2 | 31(16.8) | 97(17.8) | |
| G3 | 7(3.8) | 12(2.2) | |
| Hepatotoxicity | 0.532 | ||
| G0-G1 | 137(74.5) | 410(75.1) | |
| G2 | 32(17.4) | 80(14.7) | |
| G3 | 15(8.2) | 56(10.3) | |
| Nephrotoxicity | 0.770 | ||
| G0-G1 | 167(90.8) | 505(92.5) | |
| G2 | 12(6.5) | 29(5.3) | |
| G3 | 5(2.7) | 12(2.2) | |
| Weight loss | 0.964 | ||
| G0-G1 | 14,478.3() | 420(76.9) | |
| G2 | 36(19.6) | 112(20.5) | |
| G3 | 4(2.2) | 14(2.6) |