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. 2019 Nov 19;19:191. doi: 10.1186/s12876-019-1112-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Patient’s body appearance and histological findings. a multiple erythematous macules and hyperpigmentation on the back; b, multiple erythematous macules and hyperpigmentation over the belly; c, HE staining shows bile duct epithelial cell injury, atrophy cholangiocyte, and portal tract inflammation (× 400); d, CK7 staining of cholangiocyte reveals atrophy cholangiocyte and bile duct lesion (× 100); e, HE staining shows granulomas (× 400); f, CD68 staining of macrophagocyte shows granulomas (× 100). Black arrows indicate lesions