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. 2019 Nov 19;19:318. doi: 10.1186/s12906-019-2718-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Histological evaluation of gastric epithelial dysplasia and intestinal metaplasia (H&E staining, 400×). a The model gastric epithelium displayed dysplasia pathology characterized by glandular architectural abnormalities. After WPL intervention, these dysplasia pathological alterations, especially irregularities of glandular structure, were regressed to varying degrees. n = 6 in each group. b Histological evaluation of gastric intestinal metaplasia (AB-PAS staining, 200×). Neutral mucins present in normal mucosa were stained red. Sialomucins expressed only in intestinal-type metaplasia (IM) were stained blue. Images of the model gastric epithelium depicted prominent IM lesions, which were dramatically reduced after WPL administration. n = 5 in each group