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. 2019 Nov 12;10:987. doi: 10.3389/fgene.2019.00987

Figure 2.

Figure 2

Working model for profilin regulation in the brain. Profilin pre-mRNA is methylated by Mettl3 upon binding site recognition aided by Mettl14/16 and other components of the methyltransferase complex. The m6A mark is recognized by the m6A reader FMRP (dFMRP). The marking and its recognition are required for the recruitment of splicing and processing factors. Failure to properly mark and recognize profilin pre-mRNA has deleterious consequences in brain development.