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. 2019 Sep 23;47(11):5752–5766. doi: 10.1177/0300060519875369

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Histological changes in hypothalami of hT- and hH-stressed rats 3 weeks after treatment. Representative images of H&E staining of rat hypothalami are shown at × 400 magnification. Pathological changes in nerve cells in the hT-hH group are indicated with yellow arrows. Limited pathological changes were observed in rat hypothalami in the control (a), hT-hH-Mi (b), and hT-hH-HQ (c) groups, while in the hT-hH group, vacuolar degeneration (d), ballooning degeneration (e), and accumulation and basophilic enhancement of nerve cells (f) were observed. Glial cell hyperplasia (g) and nerve cell atrophy (h) were also observed in the hT-hH group. hH, high-humidity; hT, high-temperature; HQ, Huang Qin Hua Shi; H&E, hematoxylin and eosin; Mi, mifepristone.