TABLE 4.

AUC, sensitivity, specificity, accuracy, PPV, and NPV of ROC models (with 95% CI) from associations of the modified HLI and the PLS lifestyle and metabolic signatures (X- and M-scores) with HCC¹

	AUC	P value2	Sensitivity	Specificity	Accuracy	PPV	NPV
HLI associations
Modified HLI	0.67 (0.61, 0.73)	—	0.63 (0.54, 0.70)	0.59 (0.50, 0.67)	0.61	0.0006	0.37
Main PLS analysis3
Lifestyle signature	0.64 (0.57, 0.70)	—	0.54 (0.46, 0.63)	0.71 (0.63, 0.78)	0.63	0.0007	0.41
Metabolic signature	0.74 (0.69, 0.80)	—	0.61 (0.52, 0.68)	0.78 (0.70, 0.84)	0.69	0.0011	0.44
Sensitivity PLS analysis4
Liver function score (LFS)	0.77 (0.72, 0.82)	—	0.70 (0.61, 0.77)	0.75 (0.67, 0.82)	0.72	0.0011	0.43
LFS + lifestyle signature	0.78 (0.73, 0.84)	0.407	0.73 (0.65, 080)	0.73 (0.65, 0.80)	0.73	0.0011	0.42
LFS + metabolic signature	0.83 (0.79, 0.88)	0.003	0.74 (0.66, 0.81)	0.80 (0.73, 0.86)	0.77	0.0015	0.45

¹The estimates for the lifestyle and metabolic signatures were computed from two separated models, and were not mutually adjusted, both in main and sensitivity analyses. HCC, hepatocellular carcinoma; HLI, healthy lifestyle index; LFS, liver function score; NPV, negative predicted value; PPV, positive predicted value; PLS, partial least squares; ROC, receiver operating characteristic curve.

² P value from the DeLong test comparing the AUCs of the models including only the LFS with the models also including the lifestyle and the metabolic signature, respectively.

³Results from the main analysis using residuals based on country (X- and M-sets) and batch (M-set only) (n = 294, X-set = 7, M-set = 133).

⁴Results from the sensitivity analysis excluding the liver function score from the M-set (n = 294, X-set = 7, M-set = 132).