Table 3.
Comparison of HIV Virologic Failure Between Age Groups of 18–49 and ≥50 Years Within 12 (Range 9–15) Months of Initiating Antiretroviral Therapy in Chongqing, China, 2008–2017
| No. of patients | No. of virologic failure (VL ≥200 copies/mL) | ||||||
|---|---|---|---|---|---|---|---|
| N | n | % (95% CI) | OR (95% CI) | p | AOR (95% CI)a | p | |
| Overall | 11,548 | 1,114 | 9.6 (9.1–10.2) | ||||
| Age group, years | |||||||
| 18–49 | 7,670 | 653 | 8.5 (7.9–9.1) | Reference 1.0 | Reference 1.0 | ||
| ≥50 | 3,878 | 461 | 11.9 (10.9–12.9) | 1.9 (1.2–3.1) | .006 | 1.8 (1.1–3.0) | <.05 |
| Calendar year of initiating ART | |||||||
| 2008–2012 (Standardized ART) | 1,255 | 274 | 21.8 | Reference 1.0 | Reference 1.0 | ||
| 2013–2017 (TDF added) | 10,293 | 840 | 8.2 | 0.3 (0.3–0.4) | <.001001 | 0.3 (0.3–0.4) | <.001 |
| HIV transmission route | |||||||
| Homosexual | 3,065 | 172 | 5.6 (4.8–6.4) | Reference 1.0 | Reference 1.0 | ||
| Heterosexual | 7,642 | 878 | 11.5 (10.8–12.2) | 2.2 (1.8–.6) | <.001 | 2.1 (1.7–2,6) | <.001 |
| IDU | 841 | 64 | 7.6 (5.8–9.4) | 1.4 (0.9–2.0) | >.05 | 1.4 (1.0–2.1) | >.05 |
| Age × transmission route | |||||||
| Age × homosexual | Reference 1.0 | Reference 1.0 | |||||
| Age × heterosexual | 1.7 (1.02–2.7) | <.05 | 1.4 (0.8–2.3) | >.05 | |||
| Age × IDU | 1.7 (0.8–3.3) | >.05 | 1.5 (0.8–3.1) | >.05 | |||
a
Adjusted for sex, marital status, CD4 count before ART initiation, WHO clinical stage before ART.
AOR, adjusted odds ratio; CI, confidence interval; IDU, injection drug use; OR, odds ratio; VL, viral load.