. 2019 Nov 13;35(11-12):1044–1053. doi: 10.1089/aid.2019.0062

Table 1.

Variables and Deficit Criteria for Frailty Index

	Variable	Deficit criteria
1.	High or low BMI	>25 or <18 kg/m²
2.	High total cholesterol	>200 mg/dL
3.	High LDL cholesterol	>100 mg/dL
4.	Low HDL cholesterol	<40 mg/dL
5.	High triglycerides	>150 mg/dL
6.	Abnormal white blood cell count	<4,000 cells/μL
7.	Hemoglobin	Male: <13.5 μmol/L; female: <12 μmol/L
8.	Elevated AST	>31 U/L
9.	Elevated ALT	>31 U/L
10.	Abnormal ALP	<38 or >126 U/L
11.	Low platelets	<150 billion/L
12.	Abnormal potassium	<3.5 or >5.3 mEq/L
13.	Elevated total bilirubin	>1.1 mg/dL
14.	CRP	>0.7 mg/L
15.	Elevated IL-6	>50th percentile of control sample^a
16.	Elevated MCP-1	>50th percentile of control sample^a
17.	Elevated sCD14	>50th percentile of control sample^a
18.	Elevated TNF-a	>50th percentile of control sample^a
19.	Elevated d-dimer	>50th percentile of control sample^a
20.	HCV	Positive^b
21.	DM	Positive^b
22.	HTN	Positive^b
23.	Hyperlipidemia	Positive^b
24.	Smoking (ever)	Positive
25.	Unemployment	Positive
26.	Current MDD	Positive
27.	Lifetime MDD	Positive

^{^a}

The control sample only includes the 92 participants who were HIV-uninfected without a lifetime history of methamphetamine use disorder (HIV−/MA−).

^{^b}

Determined by one or a combination of sources, including self-report (if previously diagnosed by an outside provider), having a prescription medication for the condition, and/or in-laboratory blood test values indicative of the condition (HCV = standard clinical antibody detection; DM = elevated A1C or fasting glucose values; HTN = elevated systolic or diastolic blood pressure; hyperlipidemia = elevated total cholesterol, LDL, or triglycerides).

ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; CRP, C-reactive protein; DM, diabetes mellitus; HCV, hepatitis C virus; HDL, high-density lipoprotein; HTN, hypertension; IL-6, interleukin-6; LDL, low-density lipoprotein; MA, methamphetamine; MCP-1, monocyte chemoattractant protein 1; MDD, major depressive disorder; sCD14, soluble CD14; TNF-a, tumor necrosis factor alpha.