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. Author manuscript; available in PMC: 2019 Nov 19.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Apr 22;500(3):717–722. doi: 10.1016/j.bbrc.2018.04.142

Fig. 4. Acceleration of fibrosis progression in HCV-HIV co-infection via AB release.

Fig. 4.

HCV-HIV co-infection induces prominent apoptotic cell death in hepatocytes. These apoptotic bodies engulfed by HSC induce pro-fibrotic activation. Increased matrix stiffness corresponding to more advanced stages of liver disease further promoted apoptosis of infected hepatocytes, thereby accelerating fibrosis development.