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. Author manuscript; available in PMC: 2020 Nov 13.
Published in final edited form as: Cell Host Microbe. 2019 Oct 24;26(5):591–600.e4. doi: 10.1016/j.chom.2019.10.001

Figure 1. RhAd52 ZIKV Vaccine Protects Non-Pregnant Mice Against ZIKV Challenge.

Figure 1.

(A) Study schematic design. IFN-αβR−/− mice were vaccinated IM with 109 vp of RhAd52.M-Env (RhAd52) or PBS (Sham) and challenged IV with 102 PFU ZIKV-BR 4 weeks after vaccination.

(B) Log ZIKV-specific Env binding antibody titers measured by ELISA in vaccinated versus sham mice at 4 weeks after vaccination.

(C) Log ZIKV-specific microneutralization (MN50) titers in vaccinated versus sham mice at 4 weeks after vaccination.

(D) Log ZIKV viral loads measured by RT-PCR in serum from sham mice.

(E) Log ZIKV viral loads measured by RT-PCR in serum from RhAd52 vaccinated mice.

Data is representative of one experiment with 4 animals per group. Each dot represents an individual mouse. p values were calculated using Mann-Whitney U. Mean ± SEM is shown. Related to Figure S1.