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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Neurobiol Dis. 2019 Jan 30;125:115–122. doi: 10.1016/j.nbd.2019.01.012

Fig 4. Glutamate and ACh involvement in THP mechanism of action.

Fig 4.

(A) THP depends on nAChR to increase DA release. Blockade of nAChR with DHβE abolishes THP’s DA enhancing effects (WT n=6; Dyt1 n=6). (B) THP does not depend on glutamate signaling to increase DA release. Blockade of glutamate receptors does not alter THP’s DA-enhancing effect (WT n=4; Dyt1 n=4). Values represent mean [DA] ± SEM.