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. Author manuscript; available in PMC: 2019 Nov 19.
Published in final edited form as: J Med Chem. 2018 Dec 19;62(2):987–992. doi: 10.1021/acs.jmedchem.8b01723

Figure 1. Crystal Structure of Human AC in Covalent Complex with the Carmofur Fatty Acid Moiety.

Figure 1.

(A) Ribbon diagram (α-subunit in magenta, β-subunit in cyan) of the covalent complex. The inhibitor fatty acid moiety is shown in yellow sticks. The side chains of N-glycosylated Asn173, Asn259, Asn286, and Asn342 are shown in cyan sticks and modeled sugar units are shown in orange sticks. One disulfide bond, Cys31-Cys340, is shown in yellow. The N- and C-termini are labeled. (B) Superposition of the covalent complex (cyan) and apo-form of AC (magenta) crystal structures. The two structures are superimposed by aligning all Cα atoms of β-subunits and are presented as cartoon diagrams.