Summary of findings 2. Present‐centered therapy compared to trauma‐focused cognitive behavioral therapy for post‐traumatic stress disorder (PTSD) in adults.
| Present‐centered therapy compared to trauma‐focused cognitive behavioral therapy for post‐traumatic stress disorder (PTSD) in adults | ||||||
| Patient or population: post‐traumatic stress disorder (PTSD) in adults Setting: Intervention: present‐centered therapy Comparison: trauma‐focused cognitive behavioral therapy | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with trauma‐focused cognitive behavioral therapy | Risk with present‐centered therapy | |||||
| CAPS PTSD severity (post‐treatment) ‐ mean difference | Median post‐treatment CAPS = 53 (range: 30 to 72) | MD 6.83 higher (1.9 higher to 11.76 higher) | ‐ | 607 (6 RCTs) | ⊕⊕⊝⊝ LOW 1 2 3 | |
| PTSD severity (post‐treatment) ‐ standardized difference | SMD 0.32 SD higher (0.08 higher to 0.56 higher) | ‐ | 1129 (9 RCTs) | ⊕⊕⊝⊝ LOW 1 2 3 | This corresponds to a clinically meaningful effect as based on current guidelines (Berliner 2019). | |
| Treatment dropout | Study population | RR 0.58 (0.49 to 0.69) | 1542 (10 RCTs) | ⊕⊕⊕⊝ MODERATE 5 | ||
| 341 per 1,000 | 198 per 1,000 (167 to 235) | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1 Statistical heterogeneity was moderate to high (I2 = 42% and 69%, respectively). Point estimates varied across meaningful thresholds as defined in the methods section.
2 Confidence interval overlapped meaningful difference as defined in the methods section.
3 3 trials used completer analysis only; raised concerns given differential dropout between groups.
5 Dropout defined differently across trials