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. 2019 Nov 18;2019(11):CD012898. doi: 10.1002/14651858.CD012898.pub2

NCT02556645.

Trial name or title A comparison of web‐prolonged exposure (Web‐PE) and present‐centered therapy (PCT) for PTSD among active‐duty military personnel
Methods RCT
Participants 18 to 65 years old; adult male and female active duty military personnel who had deployed since 9/11; seeking treatment for PTSD; PTSD according to DSM‐5; DSM‐5 Criterion A event is combat‐related or an operational experience that occurred during deployment
Interventions Web‐PE vs PCT
Outcomes Primary outcomes:
  • PTSD severity (CAPS)

  • PTSD diagnosis

  • Severity scores on measures of depression, general anxiety, anger, and PTSD‐related cognitions

  • Associated biomarkers (e.g. cortisol response to awakening, cortisol response to script‐driven imagery, salivary and serum neurosteroids)

Starting date 05/2016
Contact information Dr Carmen McLean
Center for the Treatment and Study of Anxiety
University of Pennsylvania
Philadelphia, Pennsylvania
Notes https://clinicaltrials.gov/ct2/show/NCT02556645

CAPS: Clinician Administered PTSD Scale
 DSM‐5: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
 PCT: present‐centered therapy
 PTSD: post‐traumatic stress disorder
 RCT: randomized controlled trial
 Web‐PE: web‐prolonged exposure