Table 1.
The Studies On Stage I Lung Cancer Corrected With STAS Are Shown As Reported In The Published Studies
| Study | Entity | Stage I (Number) | Results |
|---|---|---|---|
| Onozato et al.13 2013 | ADC | IA (151) IB (66) |
The presence of tumor islands was significantly associated with poor outcomes in the Stage IA cohort |
| Kadota et al.10 2015 | ADC | I (411) | The presence of STAS correlated with higher risk of distant and locoregional recurrence |
| Shiono et al.27 2016 | ADC | I (318) | STAS was closely related to poor prognosis and recurrence in stage I ADCs |
| Lu et al.21 2017 | SCC | I (249) | In stage I SCC, patients with STAS had higher incidence of locoregional recurrence and lung cancer-specific death compared to those without STAS |
| Uruga et al.42 2017 | ADC | I (208) | One-third of resected small adenocarcinomas had high STAS. Higher STAS was predictive of worse RFS |
| Dai et al16 2017 | ADC | IA (383) IB (161) |
Multivariate analysis revealed STAS to be an independent prognostic factor in stage I ADCs |
| Yanagawa et al22 2018 | SCC | I (220) | STAS was associated with recurrence and worse survival in stage I SCC, but not in stage II and III SCC |
| Yang et al19 2018 | ADC | I (242) | STAS was a significantly worse predictor for Stage I patients with lung ADC >2 cm who underwent radical lobectomy |
| Shiono et al.18 2018 | NSCLC | IA (514) | STAS is a prognostic factor of poor outcomes for sublobar resection in patients with lung cancer |
| Toyokawa et al.17 2018 | ADC | I (276) | Patients with STAS had significantly shorter RFS and OS than patients without STAS, STAS-positivity remained an independent prognostic factor for both RFS and OS |
Abbreviations: ADC, adenocarcinoma; SCC, squamous cell carcinoma; STAS, spread through air spaces; NSCLC, nonsmall cell lung carcinoma; RFS, recurrence-free survival; OS, overall survival.