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. 2019 Nov 15;14:8905–8922. doi: 10.2147/IJN.S229461

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© 2019 Hassanen et al.

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Photomicrograph of kidney tissue sections stained with H&E of (A) normal rat showing normal renal glomeruli and tubules. (B–D) CuO-NPs intoxicated rats showing (B) Cytoplasmic vacuolization (arrow) in some renal tubular epithelial cells and necrosis in other (arrowhead) associated with intraluminal hyaline cast (star). (C) Extensive renal tubular necrosis (arrow) with intensely eosinophilic cytoplasm and pyknotic nuclei with intraluminal aggregation of renal protein and cellular cast (arrowhead). (D) Necrotic tubular epithelium appearing with intensely eosinophilic cytoplasm and completely lysed nuclei (arrow) that are exfoliated in the tubular lumen. (E) CuO-NPs + 1 mL/kg bwt PJ group showing granular degeneration of renal tubular epithelium. (F) CuO-NPs + 3 mL/kg bwt PJ group showing regenerative renal tubules which are lined with large basophilic vesicular nuclei.