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. 2019 Nov 15;12:9767–9781. doi: 10.2147/OTT.S228522

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© 2019 Wang et al.

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UBE2S promoted pancreatic cancer proliferation in vivo and vitro. (A–B) UBE2S was up-regulated in cancer cell lines (BXPC3, PANC1, CAPAN2, SW1990, CFPAC1) compared with normal pancreatic ductal epithelial cell line (HPNE). (C) The two designed siRNA presented satisﬁed inhibition efﬁciency in both CFPAC1 and PANC1 cell lines. (D) UBE2S protein expression in SW1990 cells infected with pLVX-Puro-UBE2S lentivirus. (E) UBE2S knockdown inhibits proliferation. (F) UBE2S overexpression promotes proliferation. (G) UBE2S overexpression promotes the clone formation of SW1990 cells. (H) UBE2S knockdown inhibits the clone formation of PANC1 and CFPAC1 cells. (I) UBE2S promotes subcutaneous tumour growth in nude mice. (J) The tumor growth rate of the si-NC group was signiﬁcantly faster than that of the si-UBE2S group. *P<0.05, **P<0.01.