Table 2.
Factors Of Dementia By Using Cox Regression And Fine & Gray’s Competing Risk Model
| Competing Risk In The Model | ||||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Crude HR | 95% CI | 95% CI | P | Adjusted HR | 95% CI | 95% CI | P |
| HIV | ||||||||
| With | 0.682 | 0.109 | 2.576 | 0.572 | 0.852 | 0.189 | 2.886 | 0.415 |
| Gender | ||||||||
| Male | 1.443 | 0.968 | 2.151 | 0.072 | 1.483 | 0.993 | 2.214 | 0.054 |
| Age group (years) | ||||||||
| ≥65 | 0.903 | 0.678 | 1.202 | 0.484 | 0.943 | 0.704 | 1.264 | 0.696 |
| Education (years) | ||||||||
| ≥12 | 0.997 | 0.588 | 1.596 | 0.703 | 1.012 | 0.699 | 2.045 | 0.752 |
| Insured premium (NT$) | ||||||||
| <18,000 | Reference | Reference | ||||||
| 18,000–34,999 | 0.000 | – | – | 0.941 | 0.000 | – | – | 0.931 |
| ≥35,000 | 0.000 | – | – | 0.983 | 0.000 | – | – | 0.980 |
| DM | ||||||||
| With | 1.094 | 0.818 | 1.483 | 0.543 | 1.028 | 0.764 | 1.382 | 0.856 |
| HTN | ||||||||
| With | 0.839 | 0.635 | 1.110 | 0.219 | 0.813 | 0.609 | 1.086 | 0.161 |
| Hyperlipidemia | ||||||||
| With | 0.650 | 0.289 | 1.462 | 0.297 | 0.756 | 0.331 | 1.726 | 0.506 |
| CAD | ||||||||
| With | 0.725 | 0.488 | 1.123 | 0.150 | 0.736 | 0.470 | 1.154 | 0.162 |
| Obesity | ||||||||
| With | – | – | – | – | – | – | – | – |
| All cancers | ||||||||
| With | 0.288 | 0.161 | 0.514 | <0.001 | 0.312 | 0.173 | 0.561 | <0.001 |
| Depression | ||||||||
| With | 3.240 | 1.868 | 6.262 | <0.001 | 2.975 | 1.538 | 5.753 | 0.001 |
| Bipolar disorder | ||||||||
| With | 0.000 | – | – | 0.946 | 0.000 | – | – | 0.981 |
| Anxiety | ||||||||
| With | 2.585 | 0.828 | 8.073 | 0.102 | 1.278 | 0.357 | 4.571 | 0.706 |
| Alcohol use disorders | ||||||||
| With | 6.622 | 1.645 | 26.657 | 0.008 | 7.243 | 1.752 | 29.948 | 0.006 |
| Substance use disorders | ||||||||
| With | 3.928 | 0.551 | 28.034 | 0.172 | 2.521 | 0.316 | 20.086 | 0.383 |
| Insomnia | ||||||||
| With | 2.298 | 1.022 | 5.167 | 0.044 | 1.846 | 0.799 | 4.264 | 0.151 |
| CCI_R | 1.368 | 1.208 | 1.549 | <0.001 | 1.353 | 1.202 | 1.545 | <0.001 |
| Location | ||||||||
| Northern Taiwan | Reference | Multicollinearity with urbanization level | ||||||
| Middle Taiwan | 1.120 | 0.826 | 1.517 | 0.466 | Multicollinearity with urbanization level | |||
| Southern Taiwan | 0.891 | 0.839 | 1.244 | 0.498 | Multicollinearity with urbanization level | |||
| Eastern Taiwan | 1.695 | 1.096 | 2.622 | 0.018 | Multicollinearity with urbanization level | |||
| Outlets islands | 2.556 | 0.628 | 10.383 | 0.189 | Multicollinearity with urbanization level | |||
| Urbanization level | ||||||||
| 1 (The highest) | 0.651 | 0.468 | 0.907 | 0.011 | 0.852 | 0.582 | 1.248 | 0.412 |
| 2 | 0.594 | 0.434 | 0.912 | 0.001 | 0.736 | 0.528 | 1.030 | 0.074 |
| 3 | 0.566 | 0.318 | 1.007 | 0.053 | 0.559 | 0.313 | 1.000 | 0.050 |
| 4 (The lowest) | Reference | Reference | ||||||
| Level of care | ||||||||
| Medical center | 0.519 | 0.376 | 0.716 | <0.001 | 0.562 | 0.386 | 0.818 | 0.003 |
| Regional hospital | 0.642 | 0.476 | 0.865 | 0.004 | 0.673 | 0.496 | 0.914 | 0.011 |
| Local hospital | Reference | Reference | ||||||
Abbreviations: HIV, human immunodeficiency virus; NT$, New Taiwan Dollars; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease, CCI-R, Charlson Comorbidity Index, dementia removed; HR, hazard ratio, CI, confidence interval, P, Chi-square/Fisher exact test on category variables and t-test on continue variables; adjusted HR, adjusted variables listed in this table.