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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: Cell. 2019 Aug 8;178(5):1231–1244.e11. doi: 10.1016/j.cell.2019.07.033

Figure 6. GDF15 controls triglyceride metabolism to support cardiac and thermal function during sepsis.

Figure 6.

(A) Survival after intraperitoneal injection of LPS following pre-treatment with either isotype or α-GDF15 antibody and subsequent intraperitoneal injection of either PBS or Intralipid 20% at 2, 6, 22, and 30 hours post-LPS injection. (n>9 per group)

(B) Plasma troponin I levels 24 hours after LPS injection following pre-treatment with either isotype or α-GDF15 antibody with or without intraperitoneal injection of either PBS or Intralipid 20%.

(C) Rectal temperature in mice 24 hours after LPS injection following pre-treatment with either isotype or α-GDF15 antibody with or without intraperitoneal injection of either PBS or Intralipid 20%.

(D) Survival after intraperitoneal injection of LPS and subsequent injection of purified mouse GDF15 or control protein (ovalbumin) starting 6 hours post-LPS injection and twice daily thereafter. (n>14 per group, representative of 2 independent experiments using two different rGDF15 preparations)

(E) Survival after CLP and subsequent injection of purified mouse GDF15 or control protein (ovalbumin) starting 6 hours post-LPS injection and twice daily thereafter (n>9 per group).

(F) Survival in wildtype and Adrb1/2−/− animals after intraperitoneal injection of LPS and subsequent injection of purified mouse GDF15 or control protein (ovalbumin) starting 6 hours post-LPS injection and twice daily thereafter. (n>8 per group)