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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: Cell. 2019 Aug 8;178(5):1231–1244.e11. doi: 10.1016/j.cell.2019.07.033

Figure 7. Model of GDF15 regulating hepatic sympathetic outflow controlling lipid metabolism to support cardiac function.

Figure 7.

Upon inflammatory challenge, GDF15 is induced by immune and non-immune cells to control hepatic sympathetic outflow. Adrenergic signaling is required for maintaining systemic triglyceride levels necessary for supporting cardiac function during sepsis.