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Mean plasma concentrations of nalmefene following single intranasal and intramuscular administration. Doses were as follows: 3 mg IN (closed circles), 3 mg plus 0.25% (w/v) DDM IN (open circles), 1.5 mg IN (triangles), and 1.5 mg i.m. (half-filled circles). Inset: mean plasma concentrations of nalmefene between 2.5 minutes and 2 hours postdose.
