TABLE 3.
Statistical summary of treatment comparisons
| IN Administration (Test) |
Comparison (i.m. as Reference) |
Ratio (Test/Reference) of Adjusted Meansa |
90% CI for Ratio |
|---|---|---|---|
| Cmax/dose (ng/ml/mg) | |||
| 3 mg IN (trt A) | A vs. D | 65.8 | 49.6–87.2 |
| 3 mg/0.25% DDM IN (trt B) | B vs. D | 135 | 100–180 |
| 1.5 mg IN (trt C) | C vs. D | 63.4 | 46.6–86.4 |
| AUC0–inf/dose (ng·h/ml/mg) | |||
| 3 mg IN (trt A) | A vs. D | 63.1 | 53.1–74.9 |
| 3 mg/0.25% DDM IN (trt B) | B vs. D | 69.5 | 58.1–83.2 |
| 1.5 mg IN (trt C) | C vs. D | 55.4 | 45.8–67.1 |
AUC0–inf/dose, AUC per milligram of naloxone administered; Cmax/dose, Cmax per milligram of naloxone administered; trt, treatment.
a
Geometric least-squares mean ratio between treatments, expressed as a percentage of reference (i.m., treatment D).