Figure 5:

Rectification of DNA displacement on a step-defect ladder. (a) Snapshots of a simulation system (same as in Fig. 3c) during an MD simulation in which the direction of the pressure gradient along the nanochannel was reversed every 10 ns. The pressure gradient magnitude was 9.2 bar nm⁻¹. In each snapshot, the water flow direction and magnitude are represented by the arrows. (b) CoM coordinate of a poly(dT)₂₀ (solid lines) and poly(dA)₂₀ (dashed lines) during MD simulations carried out under pressure gradient of the specified magnitude alternating direction every 10 ns. The colour of the line segments indicate DNA displacements corresponding to solvent flow directed up or down the step defects.