Figure 1:

Treatment with resveratrol reduces clinical symptoms associated with TNBS-induced colitis murine model. Balb/c mice were administered intrarectally with 1mg of TNBS to induce colitis. Four groups of mice were used: Vehicle, Resveratrol, TNBS+Vehicle and TNBS+Resveratrol. The percent weight loss (A) was determined over the course of the study. (B) Survival curve of mice up to day 6 with colitis and those treated with RES. Colon lengths (C-D) were measured upon sacrifice (Day 5). Serum levels of SAA (E), MPO (F) and Lcn2 (G) were evaluated by ELISA. Endoscopy (H) was performed on mice on days 0, 3, and 5. Colonoscopy scores are provided (I). Significance (p-value: *<0.05, **<0.01, ***<0.005, ****<0.001) was determined by using one-way ANOVA and post-hoc Tukey’s test. In all data presented in the figure, 5 mice were used in each group. Data presented is representative of at least 3 independent experiments.