Table 3. Univariate and multivariable analyses of overall survival and progression free survival.
| Overall survival | Progression free survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Univariate analysis | Multivariable analysis* | |||||||
| HR**,+ | 95% CI++ | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age (≥64 yeas vs <64 years) |
1.381 | 0.438–4.355 | 0.581 | 1.443 | 0.843–2.470 | 0.181 | |||
| Histologic grade (moderately & poorly vs well) |
0.773 | 0.168–3.550 | 0.741 | 2.286 | 1.301–4.018 | 0.004 | 2.034 | 1.105–3.743 | 0.023 |
| Lymphovascular invasion (present vs absent) |
5.300 | 1.652–17.004 | 0.005 | 4.901 | 2.767–8.681 | <0.001 | 2.752 | 1.369–5.531 | 0.004 |
| Stage (III & IV vs I & II) |
7.009 | 2.210–22.228 | 0.001 | 5.197 | 2.970–9.094. | <0.001 | 2.627 | 1.323–5.216 | 0.006 |
| TILs+++ (≥50% vs <50%) |
0.032 | 0.000–8.784 | 0.230 | 0.353 | 0.151–0.825 | 0.006 | 0.389 | 0.161–0.941 | 0.036 |
*Multivariable analysis was performed with covariables showing p-value of less than 0.10 in the univariate analyses for multivariable analysis.
**The likelihood ratio test was done to ensure the proportional hazard assumptions in the Cox regression model.
+HR, hazard ratio
++CI, confidence interval
+++TILSs, tumor-infiltrating lymphocytes