Table 3.
Allele and genotype distributions in no-TRD and TRD patients for the significant variants GRIK4 rs1954787 (A) and GRIK4 rs11218030 (B).
| Table 3A | MAF (A) | Allele model | Genotypes n (frequency) | Genotype models | ||||
|---|---|---|---|---|---|---|---|---|
| n (frequency) | AA | AG | GG | Codominant | Dominant (GG vs AG + AA) | Recessive (GG + AG vs AA) | ||
| No-TRD (n = 247) | 241 (0·49) | 63 (0·25) | 115 (0·47) | 69 (0·28) | ||||
| χ2 = 5·01 p = 0·03 | F = 4·82 p = 0·03a | F = 2·94 p = 0·09a | F = 3·73 p = 0·05a | |||||
| TRD (n = 379) | 321 (0·42) | 75 (0·20) | 171 (0·45) | 133 (0·35) | ||||
| Table 3B | MAF (G) | Genotypes n (frequency) | Genotype models | |||||
| n (frequency) | Allele model | AA | AG | GG | Codominant | Dominant (AA vs AG + GG) | Recessive (AA + AG vs GG) | |
| No-TRD (n = 247) | 58 (0·12) | 195 (0·79) | 46 (0·19) | 6 (0·02) | F = 7·79 | |||
| χ2 = 5·41 p = 0·02 | F = 5·55 p = 0·02a | p = 0·005a OR = 1·67 | F = 0·14 p = 0·71a | |||||
| TRD (n = 379) | 125 (0·16) | 262 (0·69) | 109 (0·29) | 8 (0·02) | 95%C.I. = 1·15–2·44 | |||
a
p-values corrected for age and education.
MAF, minor allele frequency.