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. 2019 Nov 13;4(6):e000583. doi: 10.1136/esmoopen-2019-000583

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© Author (s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Definition of a mPFSr. (A) Algebraic definition of a mPFSr. In contrast to standard PFSr, the PFS2 interval is divided by the so-called prePFS time to correct for false positive predictions. In addition, PFS2 times above 6 months are set to 24 months to correct for false negatives (postPFS). (B) Boxplots comparing the concordance with the physician classification between PFSr and mPFSr. *p<0.05, **p<0.01, ***p<0.001. (C, D) Alluvial diagrams comparing the classification of patients from the MOSCATO 01 (C) and WINTHER (D) trials according to PFSr and mPFSr thresholds of 1.3. mPFSr, modified PFSr; PFS, progression-free survival; PFSr, PFS ratio.