TABLE I.

Process of high-shear thrombus formation. Reproduced with permission from Annu. Rev. Biomed. Eng. 19, 415–433 (2017). Copyright 2017 Annual Reviews.

1	Regions of stenosis induce high wall shear rates.
2	von Willebrand factor (vWF) attaches to the wall by adsorption onto collagen or artificial surfaces and unfolds under high-shear conditions.
3	Shear-enhanced diffusivity transports platelets to the surface and induces a high wall concentration of vWF and platelets by margination from the jostling red blood cells.
4	Circulating platelets that are not yet activated bind to surface-bound vWF.
5	Activation of adhered platelets release large amounts of vWF locally and activates integrin αIIb β3 on the platelets for firm adhesion.
6	vWF nets form on the growing thrombus as platelets are continually captured and activated.
7	The vWF nets rapidly capture billions of platelets that accumulate to form a large thrombus, with possible vessel occlusion or embolization.