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. 2019 Nov 13;13:1191. doi: 10.3389/fnins.2019.01191

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Copyright © 2019 Chen, Yang, Zhang, Wang, Bao, Gu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schwann cell migration was not modulated when knockdown of EphA4 in SCs. (A) Transfection of SCs with EphA4 siRNA-1, siRNA-2, or siRNA-3 down-regulated EphA4 expression at the protein and mRNA levels compared with transfection of fibroblasts with negative control (Scramble) (n = 3, t-test, ^***p < 0.001). (B) A transwell migration assay showed that transfection of SCs with EphA4 siRNA-3 have no effect on SC migration compared with transfection with negative control (n = 10, t-test, ^NCp = 0.4451 vs. Scramble).