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. 2019 Nov 13;13:1191. doi: 10.3389/fnins.2019.01191

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Copyright © 2019 Chen, Yang, Zhang, Wang, Bao, Gu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EphA4 negatively regulates myelination in vivo. (A,C) Representative transmission electron micrographs, obtained at 4 weeks post-surgery, of regenerated nerve in the rats treated with EphA4-siRNA (A) and EphA4 overexpression vector LV-EphA4 (C). Scale bar, 5 μm, 500 nm. (B,D) Histograms comparing G ratio, the number of myelin sheath layers, the thickness of the myelin sheath and the ratio of myelinated axons among the rats treated with EphA4-siRNA (B) and EphA4 overexpression vector LV-EphA4 (D). ^**p < 0.01, vs. scramble (B). ^**p < 0.01, vs. LV-Vector (D), t-test, n = 3 per group.