Table 1.
Baseline characteristics of patients with colorectal peritoneal metastases and successful copy number analysis (n = 52), stratified by the presence of gain of chromosome 15, chromosome 1, both chromosome 1 and 15, and no gain
| Gain Chr1 n (%) |
Gain Chr15 n (%) |
Gain Chr1&15 n (%) |
No gain n (%) |
|
|---|---|---|---|---|
| Total | 16 (100) | 16 (100) | 11 (100) | 31 (100) |
| Gender | ||||
| Male | 7 (44) | 7 (44) | 5 (45) | 11 (35) |
| Female | 9 (56) | 9 (56) | 6 (55) | 20 (65) |
| Age (median IQR) | 55 (47–65) | 56 (46–63) | 57 (46–65) | 60 (54–67) |
| Primary tumor | ||||
| Right colon | 7 (44) | 9 (56) | 6 (55) | 16 (52) |
| Left colon | 9 (56) | 7 (44) | 5 (45) | 10 (32) |
| Rectum | 0 (0) | 0 (0) | 0 (0) | 5 (16) |
| Diagnosis of PM | ||||
| Synchronousa | 9 (56) | 10 (63) | 7 (64) | 16 (52) |
| Metachronous | 7 (44) | 6 (38) | 4 (36) | 15 (48) |
| Preop. Chemo. | 9 (56) | 8 (50) | 6 (46) | 23 (74) |
| Histopathology | ||||
| Mucinous PM | 9 (56) | 11 (69) | 8 (73) | 14 (45) |
| Signet ring PM | 2 (13) | 4 (25) | 2 (18) | 2 (6) |
| PCI (median IQR) | 20 (15–24) | 21 (18–24) | 21 (18–24) | 15 (10–22) |
| CCS | ||||
| CC-0 | 14 (88) | 13 (81) | 9 (82) | 29 (94) |
| CC-1 | 2 (13) | 3 (19) | 2 (18) | 2 (6) |
| CEA (median IQR) | 33 (7–103) | 14 (4–67) | 39 (8–92) | 12 (4–39) |
| Haematog.met.b | 3 (19) | 2 (13) | 1 (9) | 3 (7) |
Values are number of cases with percentage in parentheses if not otherwise specified
CCS completeness of cytoreduction score, Chr chromosome, CN copy number, IQR interquartile range, PCI peritoneal cancer index, PM peritoneal metastases
aDiagnosis of PM within 6 months of primary tumor diagnosis
bDiagnosis of haematogenous metastasis before or at time of diagnosis of PM