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. 2019 Nov 19;9:17096. doi: 10.1038/s41598-019-52764-8

Table 2.

Interacting amino acids with First-line anti-TB drugs.

Compounds Major interacting amino acids Additional interacting amino acids
Natural substrate Y236 D256 W309 W348 K369 D372 W399 Q409
Streptomycin Y236 W348 K369 P167 G232 H396 I368 F169
Rifampicin K369
Ethambutol
Isoniazid Q200
Pyrazinamide P167 G232 I368 T168