Table 22.
Predicted absorption parameters in ADME evaluation of top hit compounds.
| Compound | Consensus Log Po/w | Consensus log S | Solubility class |
|---|---|---|---|
| 1 | 0.89 | −3.64 | soluble |
| 2 | 1.99 | −4.73 | moderately soluble |
| 3 | 0.41 | −2.85 | soluble |
| 4 | −3.64 | 0.97 | very soluble |
| 27 | −1.37 | −4.29 | moderately soluble |
| 31 | 5.41 | −7.49 | poorly soluble |
| 58 | 3.63 | −7.14 | poorly soluble |
| 59 | 3.62 | −6.86 | poorly soluble |
| 60 | 5.08 | −6.75 | poorly soluble |
| 61 | 3.51 | −4.58 | moderately soluble |
| 62 | 5.44 | −7.47 | poorly soluble |
| 63 | 3.33 | −5.03 | moderately soluble |
| 64 | 3.92 | −6.25 | poorly soluble |
| 65 | −1.63 | −2.82 | soluble |
| 66 | 5.57 | −7.2 | poorly soluble |
| 67 | 6.26 | −8.06 | poorly soluble |
| 68 | 4.74 | −6.64 | poorly soluble |
| 69 | 6.2 | −7.37 | poorly soluble |
| 70 | 5.91 | −7.67 | poorly soluble |
| 71 | 4.3 | −6.65 | poorly soluble |
| 72 | 3.63 | −6.78 | poorly soluble |
| 73 | 4.22 | −5.87 | moderately soluble |
| 74 | 4.06 | −6.7 | poorly soluble |
| 75 | 3.58 | −5.3 | moderately soluble |