Table 23.

Predicted distribution parameters in ADME evaluation of top hit compounds.

Compound	GI absorption	BBB permeant	log Kp (cm/s)
1	Low	No	−7.93
2	Low	No	−6.4
3	Low	No	−9.23
4	Low	No	−12.16
27	Low	No	−10.31
31	High	No	−5.17
58	Low	No	−6.29
59	Low	No	−6.7
60	Low	No	−5.88
61	Low	No	−6.85
62	Low	No	−5.66
63	Low	No	−8.12
64	Low	No	−7.35
65	Low	No	−12.43
66	Low	No	−5.93
67	Low	No	−5.39
68	Low	No	−6.66
69	Low	No	−4.16
70	High	No	−4.05
71	High	No	−5.76
72	High	No	−4.97
73	High	No	−5.77
74	Low	No	−5.94
75	Low	No	−6.72