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. 2019 Nov 19;9:17078. doi: 10.1038/s41598-019-53225-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PKCγ is phosphorylated in intact CST after unilateral TBI. (a) Simplified schematic illustration of unilateral TBI, CST degeneration and plasticity. Unilateral TBI causes cortical injury which affects CST degeneration (red dotted lines). CST from the contralesional, intact cortex sprouts axons that cross the midline into the denervated spinal cord after TBI (green lines). This sprouting can be anterogradely labelled by CST tracer. (b) Unilateral TBI of left cortex destroyed the right dorsal CST (dCST) in the cervical spinal cord. Cervical spinal cord sections derived from 2 weeks post-injured mice were immunostained with SMI-31 or MAG antibody. The lower panel showed the relative immune-intensity of right dCST to the contralateral dCST. (c) Immunofluorescence (IF) staining showed an increase of p-PKCγ expression in left dCST and a decrease in the right dCST in the cervical spinal cord after TBI. The immune-intensity of p-PKCγ in the left or right dCST was compared to homolateral dCST in Sham spinal cords. Data are expressed as mean ± SD (n = 3 animals in each group) and compared by Student’s t-test (**p < 0.01 vs Sham). Scale bars, 50 μm.