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. 2019 Nov 19;9:17045. doi: 10.1038/s41598-019-52624-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression changes of IL-1β, IL-4, IL-6, IL-10, IL-12, IFN-γ, TNF-α and TGF-β in the cell supernatant were showed in (A), and the representative gel of the Western Blot were shown in (B) (a), and the graph of the quantified band density were also shown in (B) (b). Data are shown as mean ± SD of 3 mice per group. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus PBS group; ^△P < 0.05, ^△△P < 0.01, ^△△△P < 0.001 versus HT-TsKaSPI group; ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus FCA/FIA group; ^§P < 0.05, ^§§P < 0.01, ^§§§P < 0.001 for TsKaSPI vs TsAdSPI.