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. 2019 Nov 19;9:17100. doi: 10.1038/s41598-019-52943-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic presentation of the undernourishment in utero mouse model: male offspring under an obesogenic diet. Cohort 1: After weaning, NN pups from ad libitum NN dams and UN pups from calorie-restricted UN dams were fed a regular chow diet up to 9 weeks. Cohort 2: High-fat diet (HFD) between 9 and 17 weeks. Cohort 3: Pups were randomly subdivided into vehicle groups (NN-Veh and UN-Veh) and TUDCA-treated groups (NN-TU and UN-TU) still under HFD up to 22 weeks.