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. 2019 Nov 19;9:17094. doi: 10.1038/s41598-019-53519-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Slitrk2 acts through its C-terminal PDZ-mediated interactions to promote excitatory synaptic transmission in CA1 hippocampal pyramidal neurons in vivo. (A–C) Representative traces (A) and summary graphs showing the frequency (B) and amplitude (C) of mEPSCs recorded from hippocampal CA1 pyramidal neurons infected with the indicated AAVs. Bar graphs show means ± SEMs (*p < 0.05, **p < 0.01; non-parametric Kruskal-Wallis test with Dunn’s post hoc test; ‘n’ denotes the total number of neurons analyzed as follows: Ctrl, n = 15 cells from 8 mice; Slitrk2 KD, n = 14 cells from 7 mice; Slitrk2 KD + WT rescue, n = 16 cells from 6 mice; Slitrk2 KD + ΔPBM rescue, n = 17 cells from 7 mice). (D–F) Representative traces (D) and summary graphs showing the frequency (E) and amplitude (F) of mIPSCs recorded from hippocampal CA1 pyramidal neurons infected with the indicated AAVs. Graphs show means ± SEMs (non-parametric Kruskal-Wallis test with Dunn’s post hoc test; ‘n’ denotes the total number of neurons analyzed as follows: Ctrl, n = 20 cells from 5 mice; Slitrk2 KD, n = 12 cells from 5 mice; Slitrk2 KD + WT rescue, n = 17 cells from 5 mice; Slitrk2 KD + ΔPBM rescue, n = 14 cells from 4 mice).