Table 4.

Statistically significant associations of the frequently mutated genes with clinico-pathological variables.

Genes	ARID1A		p-value	ARID2		p-value	PARD3		p-value
Variables	wt	mut		wt	mut		wt	mut
total	108	6		106	8		107	7
Histological subtype			0.177			0.564			0.512
NM	42	4		42	4		44	2
SSM	66	2		64	4		63	5
Tumor stage			0.608			0.094			0.515
pT1 + pT2	26	2		28	0		27	1
pT3 + pT4	82	4		78	8		80	6
Location			0.024			0.167			0.165
Sun non-exposed	68	1		66	3		63	6
Sun exposed	40	5		40	5		44	1
Age			0.965			0.024			0.046
≤median	55	3		57	1		57	1
>median	53	3		49	7		50	6

Sun exposed location = head, lower- and upper extremities; sun non-exposed location = trunk. P-values are based on Chi-squared tests, all significant p-values are indicated in bold. NM – nodular melanoma, SSM - superficial spreading melanoma. The full list of statistical associations of frequently mutated genes with clinic-pathological variables is in Supplementary Table 2.