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. 2019 Nov 19;9:17034. doi: 10.1038/s41598-019-53579-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Placental abnormalities in pregnancies sired by a JWH-133 treated father. (A) Representative images of E13.5 and E18.5 placentas from JWH-133 exposed and control (CTRL) fathers. (B) Scatter plots of placental weight at E13.5 and E18.5 from JWH-133 exposed and control (CTRL) fathers showing a significant reduction in those from treated males (E13.5: 85.71 ± 13.20 mg in JWH-133 vs 97.82 ± 12.22 mg in CTRL; E18.5: 95.22 ± 10.87 mg in JWH-133 vs 105.3 ± 8.48 mg in CTRL). Scatter plots show the results of n = 15–18 placentas randomly selected from n = 3 females from each group. *P < 0.05; **P < 0.01. (C) Histology of E18.5 placenta cross-sections from fetus sired by CTRL or by JWH-133 father stained with PAS. The spongiotrophoblast (Sp) and the labyrinth (La) are outlined manually showing a thinner Sp layer in the placenta from JWH-133 treated male. (D) Scatter plot of the ratio of Sp/total area in placentas from CTRL and JWH-133 male (33.83% ± 2.401 in JWH-133 vs 42.00% ± 1.265 in CTRL) (E) Scatter plot of the ratio of La/total area in placenta from CTRL and JWH-133 male (64.00% ± 2.366 in JWH-133 vs 57.50% ± 1.049 in CTRL). The areas were measured by using five sections for each placenta. Scatter plots show the results of n = 6 placentas randomly selected from each group. ***P < 0.001; ****P < 0.0001. Scale bar: 1 mm in C.