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. 2019 Nov 19;9:17024. doi: 10.1038/s41598-019-53502-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Higher ROS in FANCD2-deprived cells does not mediate increased SAHF. (A) Histogram presenting the relative intracellular ROS level in FANCD2-proficient and FANCD2-deficient IMR90* cells before oncogene activation (left) and 2 or 4 days after oncogene activation in control cells (right). Bars represent the mean +/− SEM of 3 independent experiments. *p < 0.05. (B) Histogram presenting the relative intracellular ROS level in FANCD2-proficient and FANCD2-deficient IMR90* cells 4 days after oncogene activation in the absence or presence of the NAC (2.5 mM). Bars represent the mean +/− SEM of 3 independent experiments. *p < 0.05. (C) Histogram presenting the frequency of SAHF-positive cells in FANCD2-proficient and FANCD2-deficient IMR90* cells 4 days after oncogene activation in the absence or presence of the NAC (2.5 mM). Bars represent the mean +/− SEM of 3 independent experiments.