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. 2019 Nov 19;9:17053. doi: 10.1038/s41598-019-53307-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Frames obtained from rotational 3D visualizations of a type 3 neovascularization. The 3D OCTA visualization (left image) demonstrates the presence of an intraretinal lesion originating from the deep vascular complex and moving toward the outer retinal layers. The merged 3D structural OCT (white signal) and OCTA (magenta signal) visualization (right image) allowed to investigate correlations between flow and structural data. The orientation of type 3 lesions was assessed in relation with the three axes of the three-dimensional Cartesian coordinate system, assuming that the xy-plane passes through the type 3 lesion’s origin and is parallel to the Bruch’s membrane (BM) plane.