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. 2019 Nov 19;9:17053. doi: 10.1038/s41598-019-53307-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multimodal imaging of the LE of an 82-year-old woman diagnosed with type 3 neovascularization. Multicolor (A) and infrared (B) images show areas of RPE alteration and mottling in the macula. En face OCTA images segmented at the outer retina (C) and RPE-RPE fit (D) slabs show one tuft-shaped high-flow lesion (highlighted with an orange asterisk) and presence of a sub-RPE neovascularization, respectively. The white arrow on the infrared reflectance image shows the location and direction of the OCTA B-scan (E), this displaying an high-flow vessel originating from the deep vascular complex and reaching the sub-RPE space. The 3D OCTA visualization (image F is the frame obtained by visualizing the circular region of interest highlighted on image D and visualized from the angle marked with the white eye) revealed the presence of three distinct intraretinal lesions with a filiform shape (marked with 3 asterisks), which merge in the outer retinal layers, and one sub-RPE neovascularization (white arrow).