Figure 1.

Alpha-mangostin (α-MG) treatment diminished bleomycin (BLM)-induced PF damage in mice. One week after BLM treatment (5 mg/kg), mice were intragastrically administered with α-MG (10 mg/kg) or nintedanib (40 mg/kg) once a day for 14 days. Mouse lungs were collected on day 21 after BLM treatment. The body weight (A), survival rate (B), pulmonary coefficient (C), and hydroxyproline content (G) in lungs were determined, and the representative images (HE or Masson’s trichrome staining) of pulmonary histopathological changes in mice (D) and comparisons of the inflammation score (E) and fibrosis score (F) between the experimental groups are shown. Representative H&E and Masson’s trichrome-stained tissue sections of lungs under 200 × magnification. Data were expressed as the means ± SD (n = 9). *p < 0.05, **p < 0.01, ***p < 0.001, NS, non-significant.