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. 2019 Nov 13;10:1203. doi: 10.3389/fneur.2019.01203

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Copyright © 2019 Xiao, Koepp and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Motor cortex coactivation correlates with valproic acid dosage in JME duting working memory task fMRI. Co-activation of motor and cognitive areas during a visuo-spatial working memory task was detected in JME compared with controls. The figure illustrates: (A) a negative correlation between left central activation (voxels underneath crosshair) and daily valproate dose indicating a normalizing effect of VPA on motor cortex hyperactivity. (B) Activity within the typical bilateral frontal and parietal working memory network, on the other hand, correlated positively with valproate dose, indicating a normalizing effect of valproate on the cortical activation pattern in JME. Reproduced with permission from Vollmar et al. (17).