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. 2019 Nov 13;13:59. doi: 10.3389/fnsys.2019.00059

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Copyright © 2019 Bensaid, Modolo, Merlet, Wendling and Benquet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of real and simulated intracerebral EEG (iEEG; toy model, N = 4). Left column: in the condition of high thalamo-cortical connectivity (i.e., low cortico-cortical connectivity), signals generated by the mean-field model are characterized by delta waves (~4 Hz). These simulated signals are similar (although slightly faster) to delta waves recorded by iEEG during slow wave sleep (SWS) in non-epileptic cortical regions of one patient undergoing an invasive EEG exploration. Right column: in the condition of low thalamo-cortical connectivity, signals generated by the mean-field model are similar to background activity recorded by iEEG in real conditions during wakefulness. Note that these iEEG recordings are performed in patients who are candidates to epilepsy surgery. For the sake of this study, only iEEG signals that do not show epileptic activity were retained.